Phyto-factories of anti-cancer compounds: a tissue culture perspective

Abstract Background Cancer is one of the most critical but ubiquitous causes death grappled from past decades. Widely used chemotherapy with cytotoxic activity blocks/ kills cancer cell. The compounds targeted for anticancerous are either derived synthetically or naturally (through plants microbial origin). Current day, versatile role in medicinal field has been attributed to secondary metabolites it produces, known their anticancer activity. Therefore, discovery, identification and commercial production such novel drugs escalated centerpiece pharmaceuticals. Main body A biotechnological approach, principally tissue culture, leads candidacy be an alternative method compounds. wide range bioactive agents like alkaloids, steroids, phenolics, saponins, flavonoids, terpenoids huge demand commercially. Plant culture applications constructively more advantageous over conventional methods terms continuous, controlled, aseptic production, large scale de novo synthesis opportunity. Various bioreactors mass cultivation compound at level. For example: stirred tank reactors shikonin Lithospermum erythrorhizon, vincristine Catharanthus roseus , podophyllotoxin Podophyllum etc . Strategies callus suspension hairy root opted these bioactives. Conclusions This review summarizes plant as a promising strategy proven colossal breakthrough reliable continuous existing help combating increasing future demands.